1dgn

<StructureSection load='1dgn' size='340' side='right'caption='[[1dgn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1dgn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGN FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgn OCA], [https://pdbe.org/1dgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgn RCSB], [https://www.ebi.ac.uk/pdbsum/1dgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgn ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/CAR18_HUMAN CAR18_HUMAN]] Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.<ref>PMID:11051551</ref>

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== Publication Abstract from PubMed ==

ProIL-1beta is a proinflammatory cytokine that is proteolytically processed to its active form by caspase-1. Upon receipt of a proinflammatory stimulus, an upstream adaptor, RIP2, binds and oligomerizes caspase-1 zymogen, promoting its autoactivation. ICEBERG is a novel protein that inhibits generation of IL-1beta by interacting with caspase-1 and preventing its association with RIP2. ICEBERG is induced by proinflammatory stimuli, suggesting that it may be part of a negative feedback loop. Consistent with this, enforced retroviral expression of ICEBERG inhibits lipopolysaccharide-induced IL-1beta generation. The structure of ICEBERG reveals it to be a member of the death-domain-fold superfamily. The distribution of surface charge is complementary to the homologous prodomain of caspase-1, suggesting that charge-charge interactions mediate binding of ICEBERG to the prodomain of caspase-1.

ICEBERG: a novel inhibitor of interleukin-1beta generation.,Humke EW, Shriver SK, Starovasnik MA, Fairbrother WJ, Dixit VM Cell. 2000 Sep 29;103(1):99-111. PMID:11051551<ref>PMID:11051551</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1dgn" style="background-color:#fffaf0;"></div>

[[Category: Human]]

[[Category: Dixit, V M]]

[[Category: Fairbrother, W J]]

[[Category: Humke, E W]]

[[Category: Shriver, S K]]

[[Category: Starovasnik, M A]]

[[Category: Hydrolase inhibitor]]