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7duf

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Current revision (19:32, 29 May 2024) (edit) (undo)
 
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<StructureSection load='7duf' size='340' side='right'caption='[[7duf]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
<StructureSection load='7duf' size='340' side='right'caption='[[7duf]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7duf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DUF FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DUF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORTH2, VIM1, At1g57820, F12K22.14 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7duf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7duf OCA], [https://pdbe.org/7duf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7duf RCSB], [https://www.ebi.ac.uk/pdbsum/7duf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7duf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7duf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7duf OCA], [https://pdbe.org/7duf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7duf RCSB], [https://www.ebi.ac.uk/pdbsum/7duf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7duf ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/ORTH2_ARATH ORTH2_ARATH]] E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin.<ref>PMID:17239600</ref> <ref>PMID:17242155</ref> <ref>PMID:18643997</ref> <ref>PMID:18704160</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7duf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7duf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arath]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RING-type E3 ubiquitin transferase]]
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[[Category: Abhishek S]]
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[[Category: Abhishek, S]]
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[[Category: Deeksha W]]
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[[Category: Deeksha, W]]
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[[Category: Patel DJ]]
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[[Category: Patel, D J]]
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[[Category: Rajakumara E]]
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[[Category: Rajakumara, E]]
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[[Category: Arabidopsis]]
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[[Category: Ligase]]
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[[Category: Orthrus 2]]
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[[Category: Phd finger]]
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[[Category: Plant homeodomain]]
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[[Category: Zinc finger]]
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Current revision

Crystal structure of VIM1 PHD finger.

PDB ID 7duf

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OCA

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