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7f65

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Current revision (17:10, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7f65' size='340' side='right'caption='[[7f65]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='7f65' size='340' side='right'caption='[[7f65]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7f65]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F65 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7f65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._MB1_'Bresler_1999' Rhodococcus sp. MB1 'Bresler 1999']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F65 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.202&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cocaine_esterase Cocaine esterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.84 3.1.1.84] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f65 OCA], [https://pdbe.org/7f65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f65 RCSB], [https://www.ebi.ac.uk/pdbsum/7f65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f65 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f65 OCA], [https://pdbe.org/7f65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f65 RCSB], [https://www.ebi.ac.uk/pdbsum/7f65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f65 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM]] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref>
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[https://www.uniprot.org/uniprot/COCE_RHOSM COCE_RHOSM] Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat.<ref>PMID:10698749</ref> <ref>PMID:16968810</ref> <ref>PMID:12369817</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7f65" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7f65" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cocaine esterase|Cocaine esterase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cocaine esterase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ouyang, P F]]
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[[Category: Rhodococcus sp. MB1 'Bresler 1999']]
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[[Category: Tong, J]]
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[[Category: Ouyang PF]]
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[[Category: Zhang, Y]]
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[[Category: Tong J]]
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[[Category: Benzoylecgonine metabolism]]
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[[Category: Zhang Y]]
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[[Category: Hydrolase]]
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[[Category: Mutantion]]
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Current revision

Bacetrial Cocaine Esterase with mutations T172R/G173Q/V116K/S117A/A51L, bound to benzoic acid

PDB ID 7f65

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