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7l4i

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Current revision (15:37, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7l4i' size='340' side='right'caption='[[7l4i]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
<StructureSection load='7l4i' size='340' side='right'caption='[[7l4i]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7l4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L4I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7l4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L4I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPM1H, ARHCL1, KIAA1157, URCC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l4i OCA], [https://pdbe.org/7l4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l4i RCSB], [https://www.ebi.ac.uk/pdbsum/7l4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l4i ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l4i OCA], [https://pdbe.org/7l4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l4i RCSB], [https://www.ebi.ac.uk/pdbsum/7l4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l4i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PPM1H_HUMAN PPM1H_HUMAN]] Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.<ref>PMID:22586611</ref>
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[https://www.uniprot.org/uniprot/PPM1H_HUMAN PPM1H_HUMAN] Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.<ref>PMID:22586611</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Khan AR]]
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[[Category: Khan, A R]]
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[[Category: Waschbusch D]]
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[[Category: Waschbusch, D]]
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[[Category: Hydrolase]]
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[[Category: Lrrk2 kinase]]
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[[Category: Membrane trafficking]]
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[[Category: Pp2c/ppm family]]
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[[Category: Rab gtpase]]
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Current revision

Crystal structure of a substrate-trapping variant of PPM1H phosphatase

PDB ID 7l4i

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