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7n0z

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Current revision (16:22, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7n0z' size='340' side='right'caption='[[7n0z]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='7n0z' size='340' side='right'caption='[[7n0z]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7n0z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N0Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7n0z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N0Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPM1H, ARHCL1, KIAA1157, URCC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n0z OCA], [https://pdbe.org/7n0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n0z RCSB], [https://www.ebi.ac.uk/pdbsum/7n0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n0z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n0z OCA], [https://pdbe.org/7n0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n0z RCSB], [https://www.ebi.ac.uk/pdbsum/7n0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n0z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PPM1H_HUMAN PPM1H_HUMAN]] Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.<ref>PMID:22586611</ref>
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[https://www.uniprot.org/uniprot/PPM1H_HUMAN PPM1H_HUMAN] Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.<ref>PMID:22586611</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Khan, A R]]
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[[Category: Khan AR]]
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[[Category: Waschbusch, D]]
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[[Category: Waschbusch D]]
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[[Category: Hydrolase]]
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Current revision

Structure of PPM1H phosphatase with manganese ions at the active site

PDB ID 7n0z

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