7ssm
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ssm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ssm OCA], [https://pdbe.org/7ssm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ssm RCSB], [https://www.ebi.ac.uk/pdbsum/7ssm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ssm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ssm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ssm OCA], [https://pdbe.org/7ssm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ssm RCSB], [https://www.ebi.ac.uk/pdbsum/7ssm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ssm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The identification of agonists of the stimulator of interferon genes (STING) pathway has been an area of intense research due to their potential to enhance innate immune response and tumor immunogenicity in the context of immuno-oncology therapy. Initial efforts to identify STING agonists focused on the modification of 2',3'-cGAMP (1) (an endogenous STING activator ligand) and other closely related cyclic dinucleotides (CDNs). While these efforts have successfully identified novel CDNs that have progressed into the clinic, their utility is currently limited to patients with solid tumors that STING agonists can be delivered to intratumorally. Herein, we report the discovery of a unique class of non-nucleotide small-molecule STING agonists that demonstrate antitumor activity when dosed intratumorally in a syngeneic mouse model. | ||
| + | |||
| + | Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.,Cherney EC, Zhang L, Lo J, Huynh T, Wei D, Ahuja V, Quesnelle C, Schieven GL, Futran A, Locke GA, Lin Z, Monereau L, Chaudhry C, Blum J, Li S, Fereshteh M, Li-Wang B, Gangwar S, Pan C, Chong C, Zhu X, Posy SL, Sack JS, Zhang P, Ruzanov M, Harner M, Akhtar F, Schroeder GM, Vite G, Fink B J Med Chem. 2022 Feb 2. doi: 10.1021/acs.jmedchem.1c01986. PMID:35108011<ref>PMID:35108011</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ssm" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:45, 23 February 2022
Crystal structure of human STING R232 in complex with compound 11
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