1dr9
From Proteopedia
(New page: 200px<br /> <applet load="1dr9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dr9, resolution 3.00Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1dr9.gif|left|200px]]<br /> | + | [[Image:1dr9.gif|left|200px]]<br /><applet load="1dr9" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1dr9" size=" | + | |
caption="1dr9, resolution 3.00Å" /> | caption="1dr9, resolution 3.00Å" /> | ||
'''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)'''<br /> | '''CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on | + | B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on antigen-presenting cells. The binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates costimulatory and inhibitory signals in T cells, respectively. The crystal structure of the extracellular region of B7-1 (sB7-1), solved to 3 A resolution, consists of a novel combination of two Ig-like domains, one characteristic of adhesion molecules and the other previously seen only in antigen receptors. In the crystal lattice, sB7-1 unexpectedly forms parallel, 2-fold rotationally symmetric homodimers. Analytical ultracentrifugation reveals that sB7-1 also dimerizes in solution. The structural data suggest a mechanism whereby the avidity-enhanced binding of B7-1 and CTLA-4 homodimers, along with the relatively high affinity of these interactions, favors the formation of very stable inhibitory signaling complexes. |
==About this Structure== | ==About this Structure== | ||
| - | 1DR9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1DR9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DR9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Davis, S | + | [[Category: Davis, S J.]] |
[[Category: Ikemizu, S.]] | [[Category: Ikemizu, S.]] | ||
| - | [[Category: Jones, E | + | [[Category: Jones, E Y.]] |
| - | [[Category: Stuart, D | + | [[Category: Stuart, D I.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: ig superfamily]] | [[Category: ig superfamily]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:37 2008'' |
Revision as of 10:19, 21 February 2008
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CRYSTAL STRUCTURE OF A SOLUBLE FORM OF B7-1 (CD80)
Overview
B7-1 (CD80) and B7-2 (CD86) are glycoproteins expressed on antigen-presenting cells. The binding of these molecules to the T cell homodimers CD28 and CTLA-4 (CD152) generates costimulatory and inhibitory signals in T cells, respectively. The crystal structure of the extracellular region of B7-1 (sB7-1), solved to 3 A resolution, consists of a novel combination of two Ig-like domains, one characteristic of adhesion molecules and the other previously seen only in antigen receptors. In the crystal lattice, sB7-1 unexpectedly forms parallel, 2-fold rotationally symmetric homodimers. Analytical ultracentrifugation reveals that sB7-1 also dimerizes in solution. The structural data suggest a mechanism whereby the avidity-enhanced binding of B7-1 and CTLA-4 homodimers, along with the relatively high affinity of these interactions, favors the formation of very stable inhibitory signaling complexes.
About this Structure
1DR9 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure and dimerization of a soluble form of B7-1., Ikemizu S, Gilbert RJ, Fennelly JA, Collins AV, Harlos K, Jones EY, Stuart DI, Davis SJ, Immunity. 2000 Jan;12(1):51-60. PMID:10661405
Page seeded by OCA on Thu Feb 21 12:19:37 2008
