1geg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1geg.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1geg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1geg| PDB=1geg | SCENE= }}
{{STRUCTURE_1geg| PDB=1geg | SCENE= }}
-
'''CRYATAL STRUCTURE ANALYSIS OF MESO-2,3-BUTANEDIOL DEHYDROGENASE'''
+
===CRYATAL STRUCTURE ANALYSIS OF MESO-2,3-BUTANEDIOL DEHYDROGENASE===
-
==Overview==
+
<!--
-
The crystal structure of a ternary complex of meso-2,3-butanediol dehydrogenase with NAD+ and a competitive inhibitor, mercaptoethanol, has been determined at 1.7 A resolution by means of molecular replacement and refined to a final R-factor of 0.194. The overall structure is similar to those of the other short chain dehydrogenase/reductase enzymes. The NAD+ binding site, and the positions of catalytic residues Ser139, Tyr152, and Lys156 are also conserved. The crystal structure revealed that mercaptoethanol bound specifically to meso-2,3-butanediol dehydrogenase. Two residues around the active site, Gln140 and Gly183, forming hydrogen bonds with the inhibitor, are important but not sufficient for distinguishing stereoisomerism of a chiral substrate.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11173520}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11173520 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11173520}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Ui, S.]]
[[Category: Ui, S.]]
[[Category: Sdr family]]
[[Category: Sdr family]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:28:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:10:15 2008''

Revision as of 02:10, 1 July 2008

Image:1geg.png

Template:STRUCTURE 1geg

CRYATAL STRUCTURE ANALYSIS OF MESO-2,3-BUTANEDIOL DEHYDROGENASE

Template:ABSTRACT PUBMED 11173520

About this Structure

1GEG is a Single protein structure of sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA.

Reference

Crystal structure of meso-2,3-butanediol dehydrogenase in a complex with NAD+ and inhibitor mercaptoethanol at 1.7 A resolution for understanding of chiral substrate recognition mechanisms., Otagiri M, Kurisu G, Ui S, Takusagawa Y, Ohkuma M, Kudo T, Kusunoki M, J Biochem. 2001 Feb;129(2):205-8. PMID:11173520

Page seeded by OCA on Tue Jul 1 05:10:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1geg"
Personal tools