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TGF beta signaling pathway

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[[Group:MUZIC:Myostatin]]
[[Group:MUZIC:Myostatin]]
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===Activin===
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[[Activin]]
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'''Activin A''' or '''inhibitin β chain A''' (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner<ref>PMID:16140969</ref>.
==[[TGF-beta receptor]]==
==[[TGF-beta receptor]]==
'''TGF-β receptors''' (Transforming Growth Factor) (TGFR) are serine/threonine kinase receptors. They are involved in paracrine signaling and are found in many types of tissue. TGF-β ligands include bone morphogenetic proteins, growth and initiation factors, anti-Mullerian hormone, activin, nodal TGF-β<ref>PMID:9525694</ref>. There are 3 types of TGFR: <br />
'''TGF-β receptors''' (Transforming Growth Factor) (TGFR) are serine/threonine kinase receptors. They are involved in paracrine signaling and are found in many types of tissue. TGF-β ligands include bone morphogenetic proteins, growth and initiation factors, anti-Mullerian hormone, activin, nodal TGF-β<ref>PMID:9525694</ref>. There are 3 types of TGFR: <br />

Revision as of 11:14, 22 February 2022

Human hTGFR-II extracellular domain (green) complex with TGF-β3 (grey) (PDB code 1ktz)

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References

  1. ↑ Burdette JE, Jeruss JS, Kurley SJ, Lee EJ, Woodruff TK. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Cancer Res. 2005 Sep 1;65(17):7968-75. doi: 10.1158/0008-5472.CAN-04-3553. PMID:16140969 doi:http://dx.doi.org/10.1158/0008-5472.CAN-04-3553
  2. ↑ Wrana JL. TGF-beta receptors and signalling mechanisms. Miner Electrolyte Metab. 1998;24(2-3):120-30. PMID:9525694

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