Ribosomal protein S6 kinase
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry [[2z7s]])' scene='43/434545/Cv/2'> | <StructureSection load='' size='350' side='right' caption='Human ribosomal protein S6 kinase α−1 complex with the inhibitor purvalanol (PDB entry [[2z7s]])' scene='43/434545/Cv/2'> | ||
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== Function == | == Function == | ||
[[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program. | [[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program. | ||
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== Structural highlights == | == Structural highlights == | ||
The <scene name='43/434545/Cv/5'>inhibitor purvalanol binds hRPS6K in the ATP-binding pocket between the N- and C-terminal lobes</scene><ref>PMID:17965187</ref>. <scene name='43/434545/Cv/6'>Active site</scene>. Water molecule are shown as red sphere. | The <scene name='43/434545/Cv/5'>inhibitor purvalanol binds hRPS6K in the ATP-binding pocket between the N- and C-terminal lobes</scene><ref>PMID:17965187</ref>. <scene name='43/434545/Cv/6'>Active site</scene>. Water molecule are shown as red sphere. | ||
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== 3D Structures of Ribosomal protein S6 kinase == | == 3D Structures of Ribosomal protein S6 kinase == | ||
| - | + | [[Ribosomal protein S6 kinase 3D structures]] | |
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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== References == | == References == | ||
<references/> | <references/> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:22, 19 October 2023
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