7wix
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP== | |
| - | + | <StructureSection load='7wix' size='340' side='right'caption='[[7wix]], [[Resolution|resolution]] 3.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7wix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wix OCA], [https://pdbe.org/7wix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wix RCSB], [https://www.ebi.ac.uk/pdbsum/7wix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wix ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IRTA_MYCTU IRTA_MYCTU] Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).[UniProtKB:G7CBF5]<ref>PMID:16385031</ref> <ref>PMID:19948799</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Rao Z]] | ||
| + | [[Category: Sun S]] | ||
| + | [[Category: Yang H]] | ||
| + | [[Category: Zhang B]] | ||
Revision as of 06:31, 25 January 2023
Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP
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