7wrp
From Proteopedia
(Difference between revisions)
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==Crystal Structure of pks13-ACP domain from Corynebacterium diphtheriae== | ==Crystal Structure of pks13-ACP domain from Corynebacterium diphtheriae== | ||
| - | <StructureSection load='7wrp' size='340' side='right'caption='[[7wrp]]' scene=''> | + | <StructureSection load='7wrp' size='340' side='right'caption='[[7wrp]], [[Resolution|resolution]] 1.79Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WRP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae_C7_(beta) Corynebacterium diphtheriae C7 (beta)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WRP FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wrp OCA], [https://pdbe.org/7wrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wrp RCSB], [https://www.ebi.ac.uk/pdbsum/7wrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wrp ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.794Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wrp OCA], [https://pdbe.org/7wrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wrp RCSB], [https://www.ebi.ac.uk/pdbsum/7wrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wrp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q6NES8_CORDI Q6NES8_CORDI] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mycolic acids (MAs) are unique components of cell envelope of Mycobacterium or Corynebacterium and are key factors of their virulence to human. In order to develop new anti-Tuberculosis (TB) drugs, many efforts have paid on investigation of structures and functions of proteins involved in the biosynthesis pathway of MAs. FadD32 and polyketide synthase 13 (pks13) catalyze the last step of MAs synthesis. Here we present the crystal structures of FadD32 with substrates and holo-form of ACP-domain from Corynebacterium diphtheriae. The crystal structures and in vitro biochemical assays provide new insights into the assembly of FadD32 and pks13. | ||
| + | |||
| + | Crystal structures of FadD32 and pks13-ACP domain from Corynebacterium diphtheriae.,Chen R, Yuan J, Shi X, Tang W, Liu X Biochem Biophys Res Commun. 2022 Jan 29;590:152-157. doi:, 10.1016/j.bbrc.2021.12.083. Epub 2021 Dec 25. PMID:34974304<ref>PMID:34974304</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7wrp" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Liu X]] | [[Category: Liu X]] | ||
Current revision
Crystal Structure of pks13-ACP domain from Corynebacterium diphtheriae
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