1jxs
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor== | ==Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor== | ||
| - | <StructureSection load='1jxs' size='340' side='right'caption='[[1jxs | + | <StructureSection load='1jxs' size='340' side='right'caption='[[1jxs]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1jxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1jxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxs OCA], [https://pdbe.org/1jxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxs RCSB], [https://www.ebi.ac.uk/pdbsum/1jxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxs OCA], [https://pdbe.org/1jxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxs RCSB], [https://www.ebi.ac.uk/pdbsum/1jxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/FOXK2_HUMAN FOXK2_HUMAN] Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements.<ref>PMID:1909027</ref> <ref>PMID:1339390</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 19: | Line 19: | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxs ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxs ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Interleukin enhancer binding factor (ILF) binds to the interleukin-2 (IL-2) promoter and regulates IL-2 gene expression. In this study, the 3D structure of the DNA-binding domain of ILF was determined by multidimensional NMR spectroscopy. NMR structure analysis revealed that the DNA-binding domain of ILF is a new member of the winged helix/forkhead family, and that its wing 2 contains an extra alpha-helix. This is the first study to report the presence of a C-terminal alpha-helix in place of a typical wing 2 in a member of this family. This structural difference may be responsible for the different DNA-binding specificity of ILF compared to other winged helix/forkhead proteins. Our deletion studies of the fragments of ILF also suggest that the C-terminal region plays a regulatory role in DNA binding. | ||
| - | |||
| - | Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a).,Liu PP, Chen YC, Li C, Hsieh YH, Chen SW, Chen SH, Jeng WY, Chuang WJ Proteins. 2002 Dec 1;49(4):543-53. PMID:12402362<ref>PMID:12402362</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1jxs" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chen | + | [[Category: Chen SH]] |
| - | [[Category: Chen | + | [[Category: Chen SW]] |
| - | [[Category: Chuang | + | [[Category: Chuang WJ]] |
| - | [[Category: Hsieh | + | [[Category: Hsieh YH]] |
| - | [[Category: Jeng | + | [[Category: Jeng WY]] |
| - | [[Category: Li | + | [[Category: Li C]] |
| - | [[Category: Liu | + | [[Category: Liu PP]] |
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 07:55, 3 April 2024
Solution Structure of the DNA-Binding Domain of Interleukin Enhancer Binding Factor
| |||||||||||
Categories: Homo sapiens | Large Structures | Chen SH | Chen SW | Chuang WJ | Hsieh YH | Jeng WY | Li C | Liu PP
