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7er9

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Current revision (17:00, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7er9' size='340' side='right'caption='[[7er9]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
<StructureSection load='7er9' size='340' side='right'caption='[[7er9]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7er9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7er9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ER9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ER9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TEI:2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC+ACID'>TEI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TEI:2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC+ACID'>TEI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er9 OCA], [https://pdbe.org/7er9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er9 RCSB], [https://www.ebi.ac.uk/pdbsum/7er9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7er9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7er9 OCA], [https://pdbe.org/7er9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7er9 RCSB], [https://www.ebi.ac.uk/pdbsum/7er9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7er9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN]] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
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[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7er9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7er9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Flavin reductase|Flavin reductase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Griesinger, C]]
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[[Category: Griesinger C]]
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[[Category: Ha, J H]]
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[[Category: Ha JH]]
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[[Category: Kim, M]]
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[[Category: Kim M]]
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[[Category: Lee, D]]
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[[Category: Lee D]]
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[[Category: Ryu, K S]]
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[[Category: Ryu KS]]
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[[Category: Biliverdin reductase b]]
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[[Category: Blvrb]]
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[[Category: Febuxostat]]
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[[Category: Inhibitor]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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[[Category: Platelet]]
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Current revision

Crystal structure of human Biliverdin IX-beta reductase B with Febuxostat (TEI)

PDB ID 7er9

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