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7w0g
From Proteopedia
(Difference between revisions)
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<StructureSection load='7w0g' size='340' side='right'caption='[[7w0g]], [[Resolution|resolution]] 2.44Å' scene=''> | <StructureSection load='7w0g' size='340' side='right'caption='[[7w0g]], [[Resolution|resolution]] 2.44Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W0G FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=85B:2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic+acid'>85B</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.443Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=85B:2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic+acid'>85B</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0g OCA], [https://pdbe.org/7w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0g RCSB], [https://www.ebi.ac.uk/pdbsum/7w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0g OCA], [https://pdbe.org/7w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0g RCSB], [https://www.ebi.ac.uk/pdbsum/7w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7w0g" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7w0g" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dai | + | [[Category: Dai L]] |
| - | [[Category: Feng | + | [[Category: Feng ZQ]] |
| - | [[Category: Sun | + | [[Category: Sun HB]] |
| - | [[Category: Yuan | + | [[Category: Yuan HL]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Human PPAR delta ligand binding domain in complex with a synthetic agonist H11
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Categories: Large Structures | Dai L | Feng ZQ | Sun HB | Yuan HL
