3f2n

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Current revision (15:25, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3f2n' size='340' side='right'caption='[[3f2n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3f2n' size='340' side='right'caption='[[3f2n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IZZ:(2S)-2-{[3-(3-AMINOPHENYL)IMIDAZO[1,2-B]PYRIDAZIN-6-YL]AMINO}-3-METHYLBUTAN-1-OL'>IZZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HASPIN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IZZ:(2S)-2-{[3-(3-AMINOPHENYL)IMIDAZO[1,2-B]PYRIDAZIN-6-YL]AMINO}-3-METHYLBUTAN-1-OL'>IZZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2n OCA], [https://pdbe.org/3f2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2n RCSB], [https://www.ebi.ac.uk/pdbsum/3f2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2n OCA], [https://pdbe.org/3f2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2n RCSB], [https://www.ebi.ac.uk/pdbsum/3f2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN]] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
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[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Burgess-Brown N]]
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[[Category: Burgess-Brown, N]]
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[[Category: Edwards AM]]
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[[Category: Delft, F Von]]
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[[Category: Eswaran J]]
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[[Category: Edwards, A M]]
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[[Category: Fedorov O]]
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[[Category: Eswaran, J]]
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[[Category: Filippakopoulos P]]
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[[Category: Fedorov, O]]
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[[Category: Keates T]]
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[[Category: Filippakopoulos, P]]
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[[Category: Knapp S]]
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[[Category: Keates, T]]
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[[Category: Murray JW]]
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[[Category: Knapp, S]]
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[[Category: Pike ACW]]
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[[Category: Murray, J W]]
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[[Category: Von Delft F]]
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[[Category: Pike, A C.W]]
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[[Category: Weigelt J]]
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[[Category: Structural genomic]]
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[[Category: Yue WW]]
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[[Category: Weigelt, J]]
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[[Category: Yue, W W]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Chromatin regulator]]
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[[Category: Germ cell associated 2]]
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[[Category: Haploid germ cell specific nuclear protein kinase]]
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[[Category: Haspin]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

PDB ID 3f2n

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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