This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7jye
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ==== | + | ==Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2== |
| - | <StructureSection load='7jye' size='340' side='right'caption='[[7jye]]' scene=''> | + | <StructureSection load='7jye' size='340' side='right'caption='[[7jye]], [[Resolution|resolution]] 2.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7jye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JYE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jye OCA], [https://pdbe.org/7jye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jye RCSB], [https://www.ebi.ac.uk/pdbsum/7jye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jye ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.551Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VQY:9-[(3~{a}~{R},6~{R},6~{a}~{R})-6-oxidanyl-3-phenyl-3~{a}-(1-phenylethenyl)-4,5,6,6~{a}-tetrahydro-1~{H}-pentalen-2-yl]nonyl+2-(trimethyl-$l^{4}-azanyl)ethyl+hydrogen+phosphate'>VQY</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jye OCA], [https://pdbe.org/7jye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jye RCSB], [https://www.ebi.ac.uk/pdbsum/7jye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jye ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Liver receptor homolog-1|Liver receptor homolog-1]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: D'Agostino EH]] |
| + | [[Category: Mays SG]] | ||
| + | [[Category: Ortlund EA]] | ||
Current revision
Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2
| |||||||||||
