7r4n
From Proteopedia
(Difference between revisions)
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==Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide== | ==Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide== | ||
| - | <StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]]' scene=''> | + | <StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r4n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RI:5-bromanyl-N-methyl-1H-indazole-3-carboxamide'>7RI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5qib|5qib]], [[5qic|5qic]], [[5qid|5qid]], [[5qie|5qie]], [[5qif|5qif]], [[5qig|5qig]], [[5qih|5qih]]</div></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(S)-2-hydroxy-acid_oxidase (S)-2-hydroxy-acid oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.15 1.1.3.15] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN]] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bezerra | + | [[Category: Bezerra, G A]] |
| - | [[Category: Bountra C]] | + | [[Category: Bountra, C]] |
| - | [[Category: Bradley | + | [[Category: Bradley, A R]] |
| - | [[Category: Brandeo-Neto J]] | + | [[Category: Brandeo-Neto, J]] |
| - | [[Category: Brennan | + | [[Category: Brennan, P E]] |
| - | [[Category: Douangamath A]] | + | [[Category: Delft, F von]] |
| - | [[Category: Edwards A]] | + | [[Category: Douangamath, A]] |
| - | [[Category: Krojer T]] | + | [[Category: Edwards, A]] |
| - | [[Category: Mackinnon S]] | + | [[Category: Krojer, T]] |
| - | [[Category: Oppermann U]] | + | [[Category: Mackinnon, S]] |
| - | [[Category: Talon R]] | + | [[Category: Oppermann, U]] |
| - | [[Category: Yue | + | [[Category: Talon, R]] |
| - | [[Category: | + | [[Category: Yue, W W]] |
| + | [[Category: Fragment screening]] | ||
| + | [[Category: Glycolate oxidase]] | ||
| + | [[Category: Hao1]] | ||
| + | [[Category: Hydroxyacid oxidase]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 07:22, 16 March 2022
Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide
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Categories: Large Structures | Arrowsmith, C H | Bezerra, G A | Bountra, C | Bradley, A R | Brandeo-Neto, J | Brennan, P E | Delft, F von | Douangamath, A | Edwards, A | Krojer, T | Mackinnon, S | Oppermann, U | Talon, R | Yue, W W | Fragment screening | Glycolate oxidase | Hao1 | Hydroxyacid oxidase | Oxidoreductase
