7r5f
From Proteopedia
(Difference between revisions)
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==Crystal structure of YTHDF2 with compound YLI_DF_012== | ==Crystal structure of YTHDF2 with compound YLI_DF_012== | ||
| - | <StructureSection load='7r5f' size='340' side='right'caption='[[7r5f]]' scene=''> | + | <StructureSection load='7r5f' size='340' side='right'caption='[[7r5f]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R5F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r5f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R5F FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r5f OCA], [https://pdbe.org/7r5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r5f RCSB], [https://www.ebi.ac.uk/pdbsum/7r5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r5f ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I3V:5-azanyl-6-methyl-1~{H}-pyrimidine-2,4-dione'>I3V</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r5f OCA], [https://pdbe.org/7r5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r5f RCSB], [https://www.ebi.ac.uk/pdbsum/7r5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r5f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN]] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Caflisch A]] | + | [[Category: Caflisch, A]] |
| - | [[Category: Li Y]] | + | [[Category: Li, Y]] |
| - | [[Category: Nai F]] | + | [[Category: Nai, F]] |
| + | [[Category: Epitranscriptomic reader]] | ||
| + | [[Category: M6a reader]] | ||
| + | [[Category: Rna binding protein]] | ||
Revision as of 16:23, 6 July 2022
Crystal structure of YTHDF2 with compound YLI_DF_012
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