1gio

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{{STRUCTURE_1gio| PDB=1gio | SCENE= }}
{{STRUCTURE_1gio| PDB=1gio | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES'''
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===NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES===
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==Overview==
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The three-dimensional structure of bovine angiogenin has been determined using two- and three-dimensional proton NMR spectroscopy. The solution structure is very close to that recently determined by X-ray diffraction analysis. This structure appears well defined, even if five loops and one helix exhibit greater flexibility. Analysis of the active site geometry confirms the position of the Glu-118 residue which obstructs the pyrimidine binding site. There is no experimental evidence of an unobstructed conformation of angiogenin in solution. In addition, it appears that the Glu-118 and Ser-119 residues and the cell receptor binding loop may play an important role in the differences of C-terminal fragment organization and ribonucleolytic activity observed between angiogenins and ribonuclease A.
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The line below this paragraph, {{ABSTRACT_PUBMED_8688423}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8688423 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8688423}}
==About this Structure==
==About this Structure==
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1GIO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA].
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1GIO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GIO OCA].
==Reference==
==Reference==
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[[Category: Endoribonuclease]]
[[Category: Endoribonuclease]]
[[Category: Hydrolase angiogenesis]]
[[Category: Hydrolase angiogenesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:37:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:21:19 2008''

Revision as of 02:21, 1 July 2008

Image:1gio.png

Template:STRUCTURE 1gio

NMR SOLUTION STRUCTURE OF BOVINE ANGIOGENIN, 10 STRUCTURES

Template:ABSTRACT PUBMED 8688423

About this Structure

1GIO is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy., Lequin O, Albaret C, Bontems F, Spik G, Lallemand JY, Biochemistry. 1996 Jul 9;35(27):8870-80. PMID:8688423

Page seeded by OCA on Tue Jul 1 05:21:19 2008

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