1uju

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Current revision (23:54, 27 December 2023) (edit) (undo)
 
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==Solution structure of the fourth PDZ domain of human scribble (KIAA0147 protein)==
==Solution structure of the fourth PDZ domain of human scribble (KIAA0147 protein)==
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<StructureSection load='1uju' size='340' side='right'caption='[[1uju]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1uju' size='340' side='right'caption='[[1uju]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1uju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1uju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJU FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA ha01022s1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uju OCA], [https://pdbe.org/1uju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uju RCSB], [https://www.ebi.ac.uk/pdbsum/1uju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uju ProSAT], [https://www.topsan.org/Proteins/RSGI/1uju TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uju OCA], [https://pdbe.org/1uju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uju RCSB], [https://www.ebi.ac.uk/pdbsum/1uju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uju ProSAT], [https://www.topsan.org/Proteins/RSGI/1uju TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
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[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Tochio N]]
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[[Category: Tochio, N]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Cellular signaling]]
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[[Category: Pdz domain]]
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[[Category: Rsgi]]
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[[Category: Signaling protein]]
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Current revision

Solution structure of the fourth PDZ domain of human scribble (KIAA0147 protein)

PDB ID 1uju

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