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1ul7

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Current revision (23:55, 27 December 2023) (edit) (undo)
 
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==Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3==
==Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3==
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<StructureSection load='1ul7' size='340' side='right'caption='[[1ul7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1ul7' size='340' side='right'caption='[[1ul7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ul7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UL7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ul7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UL7 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 1600015G02, Mark3, Emk2, Mpk10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ul7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ul7 OCA], [https://pdbe.org/1ul7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ul7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ul7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ul7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ul7 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ul7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ul7 OCA], [https://pdbe.org/1ul7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ul7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ul7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ul7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ul7 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MARK3_MOUSE MARK3_MOUSE]] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (By similarity).
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[https://www.uniprot.org/uniprot/MARK3_MOUSE MARK3_MOUSE] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S]]
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[[Category: Tochio N]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Tochio, N]]
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[[Category: Yokoyama, S]]
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[[Category: Elkl motif]]
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[[Category: Ka1 domain]]
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[[Category: Mark3]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Transferase]]
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Current revision

Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3

PDB ID 1ul7

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