1wgr

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Current revision (13:38, 9 May 2024) (edit) (undo)
 
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==Solution Structure of the RA Domain of Human Grb7 Protein==
==Solution Structure of the RA Domain of Human Grb7 Protein==
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<StructureSection load='1wgr' size='340' side='right'caption='[[1wgr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wgr' size='340' side='right'caption='[[1wgr]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WGR FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMS cDNA HEP10521 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgr OCA], [https://pdbe.org/1wgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgr RCSB], [https://www.ebi.ac.uk/pdbsum/1wgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgr ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgr TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wgr OCA], [https://pdbe.org/1wgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wgr RCSB], [https://www.ebi.ac.uk/pdbsum/1wgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wgr ProSAT], [https://www.topsan.org/Proteins/RSGI/1wgr TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GRB7_HUMAN GRB7_HUMAN]] Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).<ref>PMID:10893408</ref> <ref>PMID:12021278</ref> <ref>PMID:12223469</ref> <ref>PMID:20622016</ref>
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[https://www.uniprot.org/uniprot/GRB7_HUMAN GRB7_HUMAN] Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).<ref>PMID:10893408</ref> <ref>PMID:12021278</ref> <ref>PMID:12223469</ref> <ref>PMID:20622016</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Li, H]]
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[[Category: Li H]]
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[[Category: Structural genomic]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Grb7]]
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[[Category: Protein binding]]
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[[Category: Ra domain]]
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[[Category: Rsgi]]
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Current revision

Solution Structure of the RA Domain of Human Grb7 Protein

PDB ID 1wgr

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