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1x49

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Current revision (13:57, 9 May 2024) (edit) (undo)
 
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==Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase==
==Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase==
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<StructureSection load='1x49' size='340' side='right'caption='[[1x49]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1x49' size='340' side='right'caption='[[1x49]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x49]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X49 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x49]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X49 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Prkr, Eif2ak2, Pkr, Tik ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x49 OCA], [https://pdbe.org/1x49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x49 RCSB], [https://www.ebi.ac.uk/pdbsum/1x49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x49 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x49 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x49 OCA], [https://pdbe.org/1x49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x49 RCSB], [https://www.ebi.ac.uk/pdbsum/1x49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x49 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x49 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/E2AK2_MOUSE E2AK2_MOUSE]] Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest (By similarity).
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[https://www.uniprot.org/uniprot/E2AK2_MOUSE E2AK2_MOUSE] Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: He, F]]
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[[Category: He F]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Dsrm domain]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rna binding protein]]
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[[Category: Rsgi]]
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Current revision

Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase

PDB ID 1x49

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