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7ctz

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Current revision (16:16, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7ctz' size='340' side='right'caption='[[7ctz]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='7ctz' size='340' side='right'caption='[[7ctz]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7ctz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CTZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ctz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CTZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GF6:1-[3-(trifluoromethyl)phenyl]urea'>GF6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GF6:1-[3-(trifluoromethyl)phenyl]urea'>GF6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ctz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ctz OCA], [https://pdbe.org/7ctz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ctz RCSB], [https://www.ebi.ac.uk/pdbsum/7ctz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ctz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ctz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ctz OCA], [https://pdbe.org/7ctz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ctz RCSB], [https://www.ebi.ac.uk/pdbsum/7ctz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ctz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A7UD81_PLAFA A7UD81_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]
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[https://www.uniprot.org/uniprot/Q8I1R6_PLAF7 Q8I1R6_PLAF7] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vitsupakorn, D]]
 
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[[Category: Anti-folate]]
 
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[[Category: Anti-malarial]]
 
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[[Category: Antibiotic]]
 
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[[Category: Dihydrofolate reductase]]
 
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[[Category: Oxidoreductase]]
 
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Vitsupakorn D]]

Current revision

Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with fragment 148, NADPH, and dUMP

PDB ID 7ctz

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OCA

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