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3fof

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Current revision (15:30, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3fof' size='340' side='right'caption='[[3fof]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
<StructureSection load='3fof' size='340' side='right'caption='[[3fof]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fof]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FOF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fof]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FOF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2nov|2nov]], [[3foe|3foe]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parC, SP_0855 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886]), parE, SP_0852 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fof OCA], [https://pdbe.org/3fof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fof RCSB], [https://www.ebi.ac.uk/pdbsum/3fof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fof ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fof OCA], [https://pdbe.org/3fof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fof RCSB], [https://www.ebi.ac.uk/pdbsum/3fof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fof ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [[https://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
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[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fisher, L M]]
 
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[[Category: Laponogov, I]]
 
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[[Category: McAuley, K E]]
 
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[[Category: Pan, X S]]
 
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[[Category: Sanderson, M R]]
 
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[[Category: Sawhney, R]]
 
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[[Category: Sohi, M K]]
 
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[[Category: Thompson, A W]]
 
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[[Category: Veselkov, D A]]
 
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[[Category: Atp-binding]]
 
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[[Category: Cell membrane]]
 
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[[Category: Dna]]
 
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[[Category: Dna-binding]]
 
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[[Category: Isomerase]]
 
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[[Category: Isomerase-dna complex]]
 
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[[Category: Membrane]]
 
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[[Category: Moxifloxacin]]
 
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[[Category: Nucleotide-binding]]
 
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[[Category: Protein-dna cleavage complex]]
 
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[[Category: Quinolone]]
 
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Topoisomerase]]
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[[Category: Fisher LM]]
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[[Category: Laponogov I]]
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[[Category: McAuley KE]]
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[[Category: Pan X-S]]
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[[Category: Sanderson MR]]
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[[Category: Sawhney R]]
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[[Category: Sohi MK]]
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[[Category: Thompson AW]]
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[[Category: Veselkov DA]]

Current revision

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

PDB ID 3fof

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