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3fwt

From Proteopedia

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Crystal structure of Leishmania major MIF2

Structural highlights

3fwt is a 1 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q4Q412_LEIMA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Leishmania major, an intracellular parasitic protozoon that infects, differentiates and replicates within macrophages, expresses two closely related MIF-like proteins. To ascertain the roles and potential differences of these two Leishmania proteins, recombinant L. major MIF1 and MIF2 have been produced and the structures resolved by X-ray crystallography. Each has a trimeric ring architecture similar to mammalian MIF, but with some structurally distinct features. LmjMIF1, but not LmjMIF2, has tautomerase activity. LmjMIF2 is found in all life cycle stages whereas LmjMIF1 is found exclusively in amastigotes, the intracellular stage responsible for mammalian disease. The findings are consistent with parasite MIFs modulating or circumventing the host macrophage response, thereby promoting parasite survival, but suggest the LmjMIFs have potentially different biological roles. Analysis of the Leishmania braziliensis genome showed that this species lacks both MIF genes. Thus MIF is not a virulence factor in all species of Leishmania.

Structures of Leishmania major orthologues of macrophage migration inhibitory factor.,Richardson JM, Morrison LS, Bland ND, Bruce S, Coombs GH, Mottram JC, Walkinshaw MD Biochem Biophys Res Commun. 2009 Mar 13;380(3):442-8. Epub 2009 Jan 31. PMID:19187777^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Richardson JM, Morrison LS, Bland ND, Bruce S, Coombs GH, Mottram JC, Walkinshaw MD. Structures of Leishmania major orthologues of macrophage migration inhibitory factor. Biochem Biophys Res Commun. 2009 Mar 13;380(3):442-8. Epub 2009 Jan 31. PMID:19187777 doi:http://dx.doi.org/10.1016/j.bbrc.2009.01.030

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fwt"

Categories: Large Structures | Leishmania major | Richardson JM | Walkinshaw MD

@@ Line 3: / Line 3: @@
 <StructureSection load='3fwt' size='340' side='right'caption='[[3fwt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3fwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3fwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWT FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fwu|3fwu]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LmjF33.1750 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwt OCA], [https://pdbe.org/3fwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwt RCSB], [https://www.ebi.ac.uk/pdbsum/3fwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwt ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q4Q412_LEIMA Q4Q412_LEIMA]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 28: @@
 </div>
 <div class="pdbe-citations 3fwt" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]]
 == References ==
 <references/>
@@ Line 32: / Line 36: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Leima]]
+[[Category: Leishmania major]]
-[[Category: Richardson, J M]]
+[[Category: Richardson JM]]
-[[Category: Walkinshaw, M D]]
+[[Category: Walkinshaw MD]]
-[[Category: Cytokine]]
-[[Category: Homotrimer]]
-[[Category: Tautomerase]]

3fwt

From Proteopedia

Current revision

Crystal structure of Leishmania major MIF2

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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