3fwx

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Current revision (09:09, 30 October 2024) (edit) (undo)
 
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<StructureSection load='3fwx' size='340' side='right'caption='[[3fwx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3fwx' size='340' side='right'caption='[[3fwx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibc3 Vibc3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O395 Vibrio cholerae O395]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">def-1, GI:15640078, VC0395_A2473 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwx OCA], [https://pdbe.org/3fwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwx RCSB], [https://www.ebi.ac.uk/pdbsum/3fwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwx ProSAT], [https://www.topsan.org/Proteins/CSGID/3fwx TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwx OCA], [https://pdbe.org/3fwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwx RCSB], [https://www.ebi.ac.uk/pdbsum/3fwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwx ProSAT], [https://www.topsan.org/Proteins/CSGID/3fwx TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A5F4B3_VIBC3 A5F4B3_VIBC3]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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[https://www.uniprot.org/uniprot/DEF1_VIBCH DEF1_VIBCH] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwx_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vibc3]]
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[[Category: Vibrio cholerae O395]]
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[[Category: Anderson, W]]
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[[Category: Anderson W]]
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[[Category: Structural genomic]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A]]
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[[Category: Stam J]]
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[[Category: Stam, J]]
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[[Category: Zhang R]]
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[[Category: Zhang, R]]
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[[Category: Zhou M]]
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[[Category: Zhou, M]]
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[[Category: Csgid]]
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[[Category: Hydrolase]]
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[[Category: Peptide deformylase]]
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Current revision

The crystal structure of the peptide deformylase from Vibrio cholerae O1 biovar El Tor str. N16961

PDB ID 3fwx

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