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RNA uridylyltransferase

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<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'>
== Function ==
== Function ==
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'''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' (RNAU) catalyzes the addition of uridine to RNA. RNAU acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on RNAU-4 see [[Terminal Uridylyl Transferase]].
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'''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' or '''TUTase''' (TUT) catalyzes the addition of uridine to RNA. TUT acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on TUT-4 see [[Terminal Uridylyl Transferase]]. ''Drosophila melanogaster'' TUTase is called '''TUTase Tailor''' <ref>PMID:26145174</ref>.
== Structural highlights ==
== Structural highlights ==
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<scene name='53/536705/Cv/5'>RNAU-4 active site contains UTP, UMP and Mg+2 ions</scene><ref>PMID:17785418</ref>. Water molecules are shown as red spheres. <scene name='53/536705/Cv/6'>Mg coordination site</scene>.
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<scene name='53/536705/Cv/5'>TUT-4 active site contains UTP, UMP and Mg+2 ions</scene><ref>PMID:17785418</ref>. Water molecules are shown as red spheres. <scene name='53/536705/Cv/6'>Mg coordination site</scene>.
</StructureSection>
</StructureSection>

Revision as of 08:03, 9 March 2022

RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry 2q0f)

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3D Structures of RNA uridylyltransferase

Updated on 09-March-2022

References

  1. ↑ Stagno J, Aphasizheva I, Rosengarth A, Luecke H, Aphasizhev R. UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol. 2007 Feb 23;366(3):882-99. Epub 2006 Dec 2. PMID:17189640 doi:10.1016/j.jmb.2006.11.065
  2. ↑ Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell. 2015 Jul 16;59(2):217-28. doi: 10.1016/j.molcel.2015.05.034. Epub 2015 , Jul 2. PMID:26145174 doi:http://dx.doi.org/10.1016/j.molcel.2015.05.034
  3. ↑ Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14634-9. Epub 2007 Sep 4. PMID:17785418

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