1gk4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1gk4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1gk4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1gk4| PDB=1gk4 | SCENE= }}
{{STRUCTURE_1gk4| PDB=1gk4 | SCENE= }}
-
'''HUMAN VIMENTIN COIL 2B FRAGMENT (CYS2)'''
+
===HUMAN VIMENTIN COIL 2B FRAGMENT (CYS2)===
-
==Overview==
+
<!--
-
Intermediate filaments (IFs) are key components of the cytoskeleton in higher eukaryotic cells. The elementary IF 'building block' is an elongated coiled-coil dimer consisting of four consecutive alpha-helical segments. The segments 1A and 2B include highly conserved sequences and are critically involved in IF assembly. Based on the crystal structures of three human vimentin fragments at 1.4-2.3 A resolution (PDB entries 1gk4, 1gk6 and 1gk7), we have established the molecular organization of these two segments. The fragment corresponding to segment 1A forms a single, amphipatic alpha-helix, which is compatible with a coiled-coil geometry. While this segment might yield a coiled coil within an isolated dimer, monomeric 1A helices are likely to play a role in specific dimer-dimer interactions during IF assembly. The 2B segment reveals a double-stranded coiled coil, which unwinds near residue Phe351 to accommodate a 'stutter'. A fragment containing the last seven heptads of 2B interferes heavily with IF assembly and also transforms mature vimentin filaments into a new kind of structure. These results provide the first insight into the architecture and functioning of IFs at the atomic level.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11889032}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11889032 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11889032}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Parallel coiled coil]]
[[Category: Parallel coiled coil]]
[[Category: Stutter]]
[[Category: Stutter]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:40:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:25:20 2008''

Revision as of 02:25, 1 July 2008

Image:1gk4.png

Template:STRUCTURE 1gk4

HUMAN VIMENTIN COIL 2B FRAGMENT (CYS2)

Template:ABSTRACT PUBMED 11889032

About this Structure

1GK4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly., Strelkov SV, Herrmann H, Geisler N, Wedig T, Zimbelmann R, Aebi U, Burkhard P, EMBO J. 2002 Mar 15;21(6):1255-66. PMID:11889032

Page seeded by OCA on Tue Jul 1 05:25:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gk4"
Personal tools