1gk7

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{{STRUCTURE_1gk7| PDB=1gk7 | SCENE= }}
{{STRUCTURE_1gk7| PDB=1gk7 | SCENE= }}
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'''HUMAN VIMENTIN COIL 1A FRAGMENT (1A)'''
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===HUMAN VIMENTIN COIL 1A FRAGMENT (1A)===
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==Overview==
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Intermediate filaments (IFs) are key components of the cytoskeleton in higher eukaryotic cells. The elementary IF 'building block' is an elongated coiled-coil dimer consisting of four consecutive alpha-helical segments. The segments 1A and 2B include highly conserved sequences and are critically involved in IF assembly. Based on the crystal structures of three human vimentin fragments at 1.4-2.3 A resolution (PDB entries 1gk4, 1gk6 and 1gk7), we have established the molecular organization of these two segments. The fragment corresponding to segment 1A forms a single, amphipatic alpha-helix, which is compatible with a coiled-coil geometry. While this segment might yield a coiled coil within an isolated dimer, monomeric 1A helices are likely to play a role in specific dimer-dimer interactions during IF assembly. The 2B segment reveals a double-stranded coiled coil, which unwinds near residue Phe351 to accommodate a 'stutter'. A fragment containing the last seven heptads of 2B interferes heavily with IF assembly and also transforms mature vimentin filaments into a new kind of structure. These results provide the first insight into the architecture and functioning of IFs at the atomic level.
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(as it appears on PubMed at http://www.pubmed.gov), where 11889032 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11889032}}
==About this Structure==
==About this Structure==
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[[Category: Intermediate filament]]
[[Category: Intermediate filament]]
[[Category: Vimentin]]
[[Category: Vimentin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:40:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:25:31 2008''

Revision as of 02:25, 1 July 2008

Image:1gk7.png

Template:STRUCTURE 1gk7

HUMAN VIMENTIN COIL 1A FRAGMENT (1A)

Template:ABSTRACT PUBMED 11889032

About this Structure

1GK7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly., Strelkov SV, Herrmann H, Geisler N, Wedig T, Zimbelmann R, Aebi U, Burkhard P, EMBO J. 2002 Mar 15;21(6):1255-66. PMID:11889032

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