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1gl4

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{{STRUCTURE_1gl4| PDB=1gl4 | SCENE= }}
{{STRUCTURE_1gl4| PDB=1gl4 | SCENE= }}
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'''NIDOGEN-1 G2/PERLECAN IG3 COMPLEX'''
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===NIDOGEN-1 G2/PERLECAN IG3 COMPLEX===
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==Overview==
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Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa. Their high-affinity interaction, which is likely to contribute to BM assembly and function, is mediated by the central G2 domain in nidogen and the third immunoglobulin (IG)-like domain in perlecan, IG3. We have solved the crystal structure at 2.0 A resolution of the mouse nidogen-1 G2-perlecan IG3 complex. Perlecan IG3 belongs to the I-set of the IG superfamily and binds to the wall of the nidogen-1 G2 beta-barrel using beta-strands C, D and F. Nidogen-1 residues participating in the extensive interface are highly conserved, whereas the corresponding binding site on perlecan is more variable. We hypothesize that a second, as yet unidentified, activity of nidogen overlaps with perlecan binding and accounts for the unusually high degree of surface conservation in the G2 domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 11574465 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11574465}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin-like domain]]
[[Category: Immunoglobulin-like domain]]
[[Category: Proteoglycan]]
[[Category: Proteoglycan]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:42:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:27:55 2008''

Revision as of 02:27, 1 July 2008

Image:1gl4.png

Template:STRUCTURE 1gl4

NIDOGEN-1 G2/PERLECAN IG3 COMPLEX

Template:ABSTRACT PUBMED 11574465

About this Structure

1GL4 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan., Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E, EMBO J. 2001 Oct 1;20(19):5342-6. PMID:11574465

Page seeded by OCA on Tue Jul 1 05:27:55 2008

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