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3gls

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Current revision (07:07, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3gls' size='340' side='right'caption='[[3gls]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3gls' size='340' side='right'caption='[[3gls]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gls]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GLS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gls]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GLS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3glr|3glr]], [[3glt|3glt]], [[3glu|3glu]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIRT3, SIR2L3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gls OCA], [https://pdbe.org/3gls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gls RCSB], [https://www.ebi.ac.uk/pdbsum/3gls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gls ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gls OCA], [https://pdbe.org/3gls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gls RCSB], [https://www.ebi.ac.uk/pdbsum/3gls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gls ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
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[https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bemis, J E]]
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[[Category: Bemis JE]]
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[[Category: Cai, J]]
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[[Category: Cai J]]
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[[Category: Dai, H]]
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[[Category: Dai H]]
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[[Category: Jiang, Y]]
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[[Category: Jiang Y]]
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[[Category: Jin, L]]
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[[Category: Jin L]]
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[[Category: Jirousek, M R]]
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[[Category: Jirousek MR]]
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[[Category: Mao, C]]
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[[Category: Mao C]]
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[[Category: Milne, J C]]
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[[Category: Milne JC]]
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[[Category: Peng, H]]
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[[Category: Peng H]]
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[[Category: Perni, R B]]
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[[Category: Perni RB]]
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[[Category: Wei, W]]
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[[Category: Wei W]]
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[[Category: Westphal, C H]]
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[[Category: Westphal CH]]
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[[Category: Apo structure]]
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[[Category: Hydrolase]]
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[[Category: Metal-binding]]
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[[Category: Mitochondrion]]
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[[Category: Nad]]
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[[Category: Nad dependent deacetylase]]
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[[Category: Polymorphism]]
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[[Category: Sirtuin]]
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[[Category: Transit peptide]]
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[[Category: Zinc]]
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Current revision

Crystal Structure of Human SIRT3

PDB ID 3gls

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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