1glo

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{{STRUCTURE_1glo| PDB=1glo | SCENE= }}
{{STRUCTURE_1glo| PDB=1glo | SCENE= }}
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'''CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S'''
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===CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S===
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==Overview==
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Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain superfamily, plays a critical role in the generation of a major histocompatibility complex (MHC) class II restricted T-cell response by antigen-presenting cells. Therefore, selective inhibition of this enzyme may be useful in modulating class II restricted T-cell responses in immune-related disorders such as rheumatoid arthritis, multiple sclerosis and extrinsic asthma. The three-dimensional structure at 2.2 A resolution of the active-site Cys25--&gt;Ser mutant presented here in an unliganded state provides further insight useful for the design of selective enzyme inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 11856830 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11856830}}
==About this Structure==
==About this Structure==
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[[Category: Proteinase]]
[[Category: Proteinase]]
[[Category: Thiol protea]]
[[Category: Thiol protea]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:43:48 2008''
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Revision as of 02:29, 1 July 2008

Image:1glo.png

Template:STRUCTURE 1glo

CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S

Template:ABSTRACT PUBMED 11856830

About this Structure

1GLO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830

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