7wry

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'''Unreleased structure'''
 
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The entry 7wry is ON HOLD until Paper Publication
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==Local structure of BD55-3546 Fab and SARS-COV2 Delta RBD complex==
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<StructureSection load='7wry' size='340' side='right'caption='[[7wry]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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Authors: Zhang, Z.Z., Xiao, J.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7wry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/SARS_coronavirus_B012 SARS coronavirus B012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WRY FirstGlance]. <br>
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Description: Local structure of BD55-3546 Fab and SARS-COV2 Delta RBD complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wry OCA], [https://pdbe.org/7wry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wry RCSB], [https://www.ebi.ac.uk/pdbsum/7wry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wry ProSAT]</span></td></tr>
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[[Category: Zhang, Z.Z]]
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</table>
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[[Category: Xiao, J.J]]
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== Function ==
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[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: SARS coronavirus B012]]
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[[Category: Xiao JJ]]
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[[Category: Zhang ZZ]]

Revision as of 06:18, 28 September 2022

Local structure of BD55-3546 Fab and SARS-COV2 Delta RBD complex

PDB ID 7wry

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