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7lzs
From Proteopedia
(Difference between revisions)
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==Crystal structure of the BCL6 BTB domain in complex with OICR-11029== | ==Crystal structure of the BCL6 BTB domain in complex with OICR-11029== | ||
| - | <StructureSection load='7lzs' size='340' side='right'caption='[[7lzs]]' scene=''> | + | <StructureSection load='7lzs' size='340' side='right'caption='[[7lzs]], [[Resolution|resolution]] 1.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LZS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LZS FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lzs OCA], [https://pdbe.org/7lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lzs RCSB], [https://www.ebi.ac.uk/pdbsum/7lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lzs ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YJS:3-chloro-5-{7-[2-({5-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyridin-4-yl}amino)-2-oxoethyl]-3-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-hydroxybenzamide'>YJS</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lzs OCA], [https://pdbe.org/7lzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lzs RCSB], [https://www.ebi.ac.uk/pdbsum/7lzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lzs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kuntz DA]] | [[Category: Kuntz DA]] | ||
[[Category: Prive GG]] | [[Category: Prive GG]] | ||
Revision as of 06:53, 25 January 2023
Crystal structure of the BCL6 BTB domain in complex with OICR-11029
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