7pfp

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==Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament==
==Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament==
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<StructureSection load='7pfp' size='340' side='right'caption='[[7pfp]]' scene=''>
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<StructureSection load='7pfp' size='340' side='right'caption='[[7pfp]], [[Resolution|resolution]] 6.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PFP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7pfp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PFP FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pfp OCA], [https://pdbe.org/7pfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pfp RCSB], [https://www.ebi.ac.uk/pdbsum/7pfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pfp ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6tqk|6tqk]], [[6tql|6tql]], [[4wrn|4wrn]], [[7p6r|7p6r]], [[7p6s|7p6s]], [[7p6t|7p6t]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pfp OCA], [https://pdbe.org/7pfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pfp RCSB], [https://www.ebi.ac.uk/pdbsum/7pfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pfp ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/UROM_HUMAN UROM_HUMAN]] UMOD-related autosomal dominant tubulointerstitial kidney disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[https://www.uniprot.org/uniprot/UROM_HUMAN UROM_HUMAN]] Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515).<ref>PMID:20798515</ref> <ref>PMID:3498215</ref> In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.[UniProtKB:Q91X17]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy.
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Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.,Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L Nat Struct Mol Biol. 2022 Mar;29(3):190-193. doi: 10.1038/s41594-022-00729-3., Epub 2022 Mar 10. PMID:35273390<ref>PMID:35273390</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7pfp" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carroni M]]
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[[Category: Carroni, M]]
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[[Category: Jovine L]]
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[[Category: Jovine, L]]
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[[Category: Jumper J]]
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[[Category: Jumper, J]]
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[[Category: Stsiapanava A]]
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[[Category: Stsiapanava, A]]
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[[Category: Tunyasuvunakool K]]
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[[Category: Tunyasuvunakool, K]]
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[[Category: Wu B]]
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[[Category: Wu, B]]
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[[Category: Xu C]]
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[[Category: Xu, C]]
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[[Category: Antimicrobial protein]]
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[[Category: Beta-hairpin]]
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[[Category: D10c domain]]
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[[Category: Decoy module]]
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[[Category: Egf domain]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Interdomain linker]]
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[[Category: N-glycan]]
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[[Category: Protein filament]]
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[[Category: Protein polymerization]]
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[[Category: Structural protein]]
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[[Category: Zp domain]]
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[[Category: Zp module]]
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[[Category: Zp-c domain]]
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[[Category: Zp-n domain]]

Revision as of 11:58, 23 March 2022

Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament

PDB ID 7pfp

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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