7t6f

==Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain==

<StructureSection load='7t6f' size='340' side='right'caption='[[7t6f]], [[Resolution|resolution]] 3.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[7t6f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T6F FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t6f OCA], [https://pdbe.org/7t6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t6f RCSB], [https://www.ebi.ac.uk/pdbsum/7t6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t6f ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/JAK1_MOUSE JAK1_MOUSE] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.[UniProtKB:P23458]

==See Also==

*[[Janus kinase 3D structures|Janus kinase 3D structures]]

[[Category: Mus musculus]]

[[Category: Tsutsumi N]]