7wi8
From Proteopedia
(Difference between revisions)
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==Cryo-EM structure of inactive mGlu3 bound to LY341495== | ==Cryo-EM structure of inactive mGlu3 bound to LY341495== | ||
| - | <StructureSection load='7wi8' size='340' side='right'caption='[[7wi8]]' scene=''> | + | <StructureSection load='7wi8' size='340' side='right'caption='[[7wi8]], [[Resolution|resolution]] 4.17Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WI8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wi8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WI8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wi8 OCA], [https://pdbe.org/7wi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wi8 RCSB], [https://www.ebi.ac.uk/pdbsum/7wi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wi8 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wi8 OCA], [https://pdbe.org/7wi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wi8 RCSB], [https://www.ebi.ac.uk/pdbsum/7wi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wi8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Fang W]] | + | [[Category: Fang, W]] |
| - | [[Category: Lin L]] | + | [[Category: Lin, L]] |
| - | [[Category: Ling | + | [[Category: Ling, S L]] |
| - | [[Category: Liu | + | [[Category: Liu, J F]] |
| - | [[Category: Liu P]] | + | [[Category: Liu, P]] |
| - | [[Category: Pan S]] | + | [[Category: Pan, S]] |
| - | [[Category: Pin | + | [[Category: Pin, J P]] |
| - | [[Category: Rondard P]] | + | [[Category: Rondard, P]] |
| - | [[Category: Sun | + | [[Category: Sun, W J]] |
| - | [[Category: Tian | + | [[Category: Tian, C L]] |
| - | [[Category: Wang | + | [[Category: Wang, X M]] |
| - | [[Category: Xu | + | [[Category: Xu, C J]] |
| - | [[Category: Yang F]] | + | [[Category: Yang, F]] |
| - | [[Category: Zhou | + | [[Category: Zhou, Y X]] |
| + | [[Category: Cryo-em]] | ||
| + | [[Category: G protein-coupled receptor]] | ||
| + | [[Category: Glutamate]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Selective ligand]] | ||
Revision as of 07:18, 20 July 2022
Cryo-EM structure of inactive mGlu3 bound to LY341495
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Categories: Large Structures | Fang, W | Lin, L | Ling, S L | Liu, J F | Liu, P | Pan, S | Pin, J P | Rondard, P | Sun, W J | Tian, C L | Wang, X M | Xu, C J | Yang, F | Zhou, Y X | Cryo-em | G protein-coupled receptor | Glutamate | Membrane protein | Selective ligand
