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6tyl

From Proteopedia

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Current revision (07:40, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6tyl' size='340' side='right'caption='[[6tyl]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='6tyl' size='340' side='right'caption='[[6tyl]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tyl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TYL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tyl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TYL FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ric8a, rCG_48458 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gnai1, Gnai-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tyl OCA], [https://pdbe.org/6tyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tyl RCSB], [https://www.ebi.ac.uk/pdbsum/6tyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tyl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tyl OCA], [https://pdbe.org/6tyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tyl RCSB], [https://www.ebi.ac.uk/pdbsum/6tyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tyl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
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[https://www.uniprot.org/uniprot/B1H241_RAT B1H241_RAT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Lama glama]]
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[[Category: Camelus glama]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: McClelland, L]]
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[[Category: Rattus norvegicus]]
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[[Category: Mou, T C]]
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[[Category: McClelland L]]
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[[Category: Sprang, S R]]
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[[Category: Mou TC]]
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[[Category: Yates-Hansen, C]]
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[[Category: Sprang SR]]
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[[Category: G protein]]
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[[Category: Yates-Hansen C]]
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[[Category: Gef]]
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[[Category: Ric-8a]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex

PDB ID 6tyl

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