7kw4
From Proteopedia
(Difference between revisions)
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==L-DNA containing 2'-fluoro modification== | ==L-DNA containing 2'-fluoro modification== | ||
| - | <StructureSection load='7kw4' size='340' side='right'caption='[[7kw4]]' scene=''> | + | <StructureSection load='7kw4' size='340' side='right'caption='[[7kw4]], [[Resolution|resolution]] 1.03Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KW4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7kw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KW4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kw4 OCA], [https://pdbe.org/7kw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kw4 RCSB], [https://www.ebi.ac.uk/pdbsum/7kw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kw4 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.03Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DA:2-DEOXY-L-RIBO-FURANOSYL+ADENOSINE-5-MONOPHOSPHATE'>0DA</scene>, <scene name='pdbligand=0DC:2-DEOXY-L-RIBO-FURANOSYL+CYTOSINE-5-MONOPHOSPHATE'>0DC</scene>, <scene name='pdbligand=0DG:2-DEOXY-L-RIBO-FURANOSYL+GUANINE-5-MONOPHOSPHATE'>0DG</scene>, <scene name='pdbligand=0DT:2-DEOXY-L-RIBO-FURANOSYL+THYMIDINE-5-MONOPHOSPHATE'>0DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XY7:1-[2-deoxy-5-O-(dihydroxyphosphanyl)-2-fluoro-beta-L-ribofuranosyl]pyrimidine-2,4(1H,3H)-dione'>XY7</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kw4 OCA], [https://pdbe.org/7kw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kw4 RCSB], [https://www.ebi.ac.uk/pdbsum/7kw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kw4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Despite the development of artificial l-RNA/DNA as therapeutic molecules, the in-depth investigation on their chemical modifications is still limited. Here, we synthesize a chemically derivatized 2'-deoxy-2'-fluoro-l-uridine building block and incorporate it into oligonucleotides. Our thermo-denaturization and enzymatic digestion experiments reveal their superior stability. Furthermore, one crystal structure of l-type fluoro-DNA is determined to characterize its handedness. Our results reveal the increase of l-helix stability by fluoro-modification and provide the foundation for its future functional application. | ||
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| + | Synthesis and Structural Characterization of 2'-Deoxy-2'-fluoro-l-uridine Nucleic Acids.,Dantsu Y, Zhang Y, Zhang W Org Lett. 2021 Jul 2;23(13):5007-5011. doi: 10.1021/acs.orglett.1c01498. Epub, 2021 Jun 18. PMID:34142829<ref>PMID:34142829</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7kw4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
[[Category: Zhang W]] | [[Category: Zhang W]] | ||
[[Category: Zhang Y]] | [[Category: Zhang Y]] | ||
Current revision
L-DNA containing 2'-fluoro modification
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