7r4n

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Current revision (13:26, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='7r4n' size='340' side='right'caption='[[7r4n]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7r4n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7r4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RI:5-bromanyl-N-methyl-1H-indazole-3-carboxamide'>7RI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5qib|5qib]], [[5qic|5qic]], [[5qid|5qid]], [[5qie|5qie]], [[5qif|5qif]], [[5qig|5qig]], [[5qih|5qih]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7RI:5-bromanyl-N-methyl-1H-indazole-3-carboxamide'>7RI</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/(S)-2-hydroxy-acid_oxidase (S)-2-hydroxy-acid oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.15 1.1.3.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4n OCA], [https://pdbe.org/7r4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4n RCSB], [https://www.ebi.ac.uk/pdbsum/7r4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN]] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
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[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
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==See Also==
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*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bezerra, G A]]
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[[Category: Bezerra GA]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bradley, A R]]
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[[Category: Bradley AR]]
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[[Category: Brandeo-Neto, J]]
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[[Category: Brandeo-Neto J]]
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[[Category: Brennan, P E]]
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[[Category: Brennan PE]]
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[[Category: Delft, F von]]
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[[Category: Douangamath A]]
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[[Category: Douangamath, A]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Mackinnon S]]
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[[Category: Mackinnon, S]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Talon R]]
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[[Category: Talon, R]]
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[[Category: Yue WW]]
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[[Category: Yue, W W]]
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[[Category: Von Delft F]]
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[[Category: Fragment screening]]
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[[Category: Glycolate oxidase]]
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[[Category: Hao1]]
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[[Category: Hydroxyacid oxidase]]
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[[Category: Oxidoreductase]]
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Current revision

Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide

PDB ID 7r4n

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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