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3goc

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Current revision (07:08, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3goc' size='340' side='right'caption='[[3goc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3goc' size='340' side='right'caption='[[3goc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3goc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Straw Straw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GOC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3goc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avermitilis_MA-4680_=_NBRC_14893 Streptomyces avermitilis MA-4680 = NBRC 14893]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GOC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YES:3-(2-HYDROXYETHYL)-2,2-BIS(HYDROXYMETHYL)PENTANE-1,5-DIOL'>YES</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=YES:3-(2-HYDROXYETHYL)-2,2-BIS(HYDROXYMETHYL)PENTANE-1,5-DIOL'>YES</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nfi ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227882 STRAW])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Deoxyribonuclease_V Deoxyribonuclease V], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.7 3.1.21.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3goc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goc OCA], [https://pdbe.org/3goc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3goc RCSB], [https://www.ebi.ac.uk/pdbsum/3goc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3goc ProSAT], [https://www.topsan.org/Proteins/NESGC/3goc TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3goc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3goc OCA], [https://pdbe.org/3goc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3goc RCSB], [https://www.ebi.ac.uk/pdbsum/3goc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3goc ProSAT], [https://www.topsan.org/Proteins/NESGC/3goc TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NFI_STRAW NFI_STRAW]] DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).[HAMAP-Rule:MF_00801]
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[https://www.uniprot.org/uniprot/NFI_STRAW NFI_STRAW] DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity).[HAMAP-Rule:MF_00801]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Deoxyribonuclease V]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Straw]]
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[[Category: Streptomyces avermitilis MA-4680 = NBRC 14893]]
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[[Category: Abashidze, M]]
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[[Category: Abashidze M]]
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[[Category: Acton, T B]]
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[[Category: Acton TB]]
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[[Category: Chen, C X]]
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[[Category: Chen CX]]
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[[Category: Cunningham, K]]
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[[Category: Cunningham K]]
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[[Category: Everett, J K]]
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[[Category: Everett JK]]
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[[Category: Fang, F]]
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[[Category: Fang F]]
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[[Category: Forouhar, F]]
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[[Category: Forouhar F]]
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[[Category: Hunt, J F]]
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[[Category: Hunt JF]]
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[[Category: Hussain, M]]
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[[Category: Hussain M]]
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[[Category: Ma, L]]
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[[Category: Ma L]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Nair R]]
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[[Category: Nair, R]]
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[[Category: Owens L]]
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[[Category: Owens, L]]
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[[Category: Rost B]]
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[[Category: Rost, B]]
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[[Category: Seetharaman J]]
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[[Category: Seetharaman, J]]
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[[Category: Tong L]]
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[[Category: Tong, L]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: Alpha-beta protein]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Endonuclease]]
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[[Category: Hydrolase]]
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[[Category: Magnesium]]
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[[Category: Nesg]]
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[[Category: Nuclease]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal structure of the Endonuclease V (SAV1684) from Streptomyces avermitilis. Northeast Structural Genomics Consortium Target SvR196

PDB ID 3goc

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