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3gxo

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Current revision (07:13, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3gxo' size='340' side='right'caption='[[3gxo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3gxo' size='340' side='right'caption='[[3gxo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gxo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lavendulae"_waksman_and_curtis_1916 "actinomyces lavendulae" waksman and curtis 1916]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GXO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gxo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lavendulae Streptomyces lavendulae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GXO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MQA:[(1AS,8S,8AR,8BS)-6,8A-DIMETHOXY-5-METHYL-4,7-DIOXO-1,1A,2,4,7,8,8A,8B-OCTAHYDROAZIRENO[2,3 3,4]PYRROLO[1,2-A]INDOL-8-YL]METHYL+CARBAMATE'>MQA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MQA:[(1AS,8S,8AR,8BS)-6,8A-DIMETHOXY-5-METHYL-4,7-DIOXO-1,1A,2,4,7,8,8A,8B-OCTAHYDROAZIRENO[2,3 3,4]PYRROLO[1,2-A]INDOL-8-YL]METHYL+CARBAMATE'>MQA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gwz|3gwz]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mmcR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1914 "Actinomyces lavendulae" Waksman and Curtis 1916])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gxo OCA], [https://pdbe.org/3gxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gxo RCSB], [https://www.ebi.ac.uk/pdbsum/3gxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gxo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gxo OCA], [https://pdbe.org/3gxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gxo RCSB], [https://www.ebi.ac.uk/pdbsum/3gxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gxo ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMCR_STRLA MMCR_STRLA] Involved in the biosynthesis of the quinone methoxy group present in the mitomycin A and B, which are used as anticancer agents (PubMed:10099135, PubMed:17461583). In vitro, catalyzes the 6-O-methylation of both C9-beta- and C9-alpha-configured 6-hydroxymitomycins via the transfer of the S-methyl group of S-adenosyl-L-methionine (AdoMet) to the 6-demethylmitomycin A and B. It can also use hydroxyquinone as substrate (PubMed:17461583).<ref>PMID:10099135</ref> <ref>PMID:17461583</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lavendulae waksman and curtis 1916]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bingman, C A]]
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[[Category: Streptomyces lavendulae]]
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[[Category: Chang, A]]
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[[Category: Bingman CA]]
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[[Category: Phillips, G N]]
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[[Category: Chang A]]
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[[Category: Singh, S]]
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[[Category: Phillips Jr GN]]
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[[Category: Thorson, J S]]
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[[Category: Singh S]]
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[[Category: Methyltransferase]]
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[[Category: Thorson JS]]
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[[Category: Mitomycin]]
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[[Category: Mmcr]]
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[[Category: S-adenosyl methionine]]
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[[Category: Transferase]]
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Current revision

Structure of the Mitomycin 7-O-methyltransferase MmcR with bound Mitomycin A

PDB ID 3gxo

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