1go3

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{{STRUCTURE_1go3| PDB=1go3 | SCENE= }}
{{STRUCTURE_1go3| PDB=1go3 | SCENE= }}
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'''STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX'''
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===STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX===
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==Overview==
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The eukaryotic subunits RPB4 and RPB7 form a heterodimer that reversibly associates with the RNA polymerase II core and constitute the only two components of the enzyme for which no structural information is available. We have determined the crystal structure of the complex between the Methanococcus jannaschii subunits E and F, the archaeal homologs of RPB7 and RPB4. Subunit E has an elongated two-domain structure and contains two potential RNA binding motifs, while the smaller F subunit wraps around one side of subunit E, at the interface between the two domains. We propose a model for the interaction between RPB4/RPB7 and the core RNA polymerase in which the RNA binding face of RPB7 is positioned to interact with the nascent RNA transcript.
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(as it appears on PubMed at http://www.pubmed.gov), where 11741548 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11741548}}
==About this Structure==
==About this Structure==
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:35:25 2008''

Revision as of 02:35, 1 July 2008

Image:1go3.png

Template:STRUCTURE 1go3

STRUCTURE OF AN ARCHEAL HOMOLOG OF THE EUKARYOTIC RNA POLYMERASE II RPB4/RPB7 COMPLEX

Template:ABSTRACT PUBMED 11741548

About this Structure

1GO3 is a Protein complex structure of sequences from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex., Todone F, Brick P, Werner F, Weinzierl RO, Onesti S, Mol Cell. 2001 Nov;8(5):1137-43. PMID:11741548

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