7wvk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7wvk is ON HOLD until Paper Publication
+
==Crystal structure of human WDR5 in complex with compound 19==
-
 
+
<StructureSection load='7wvk' size='340' side='right'caption='[[7wvk]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[7wvk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WVK FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6IQ:1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole'>6IQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wvk OCA], [https://pdbe.org/7wvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wvk RCSB], [https://www.ebi.ac.uk/pdbsum/7wvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wvk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Bai F]]
 +
[[Category: Cao Y]]
 +
[[Category: Han QL]]
 +
[[Category: Li K]]
 +
[[Category: Ren PX]]
 +
[[Category: Wang L]]
 +
[[Category: Zhang XL]]

Revision as of 19:24, 19 October 2022

Crystal structure of human WDR5 in complex with compound 19

PDB ID 7wvk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7wvk"
Personal tools