7x5a
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of RuvA-Holliday junction complex== | |
| - | + | <StructureSection load='7x5a' size='340' side='right'caption='[[7x5a]], [[Resolution|resolution]] 3.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7x5a]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X5A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x5a OCA], [https://pdbe.org/7x5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x5a RCSB], [https://www.ebi.ac.uk/pdbsum/7x5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x5a ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Lin | + | [https://www.uniprot.org/uniprot/RUVA_PSEAE RUVA_PSEAE] The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA (By similarity). Complements an E.coli deletion mutant (PubMed:8982068).[HAMAP-Rule:MF_00031]<ref>PMID:8982068</ref> |
| - | [[Category: Zhang | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa PAO1]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Lin Z]] | ||
| + | [[Category: Qu Q]] | ||
| + | [[Category: Zhang X]] | ||
| + | [[Category: Zhou Z]] | ||
Revision as of 07:28, 8 March 2023
CryoEM structure of RuvA-Holliday junction complex
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