7npm
From Proteopedia
(Difference between revisions)
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==X-ray structure of the adduct formed upon reaction of oxaliplatin with human angiogenin== | ==X-ray structure of the adduct formed upon reaction of oxaliplatin with human angiogenin== | ||
| - | <StructureSection load='7npm' size='340' side='right'caption='[[7npm]]' scene=''> | + | <StructureSection load='7npm' size='340' side='right'caption='[[7npm]], [[Resolution|resolution]] 1.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NPM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7npm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NPM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7npm OCA], [https://pdbe.org/7npm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7npm RCSB], [https://www.ebi.ac.uk/pdbsum/7npm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7npm ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7npm OCA], [https://pdbe.org/7npm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7npm RCSB], [https://www.ebi.ac.uk/pdbsum/7npm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7npm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[https://omim.org/entry/611895 611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Angiogenin (Ang) is a potent angiogenic protein that is overexpressed in many types of cancer at concentration values correlated to the tumor aggressiveness. Here, by means of an integrated multi-technique approach based on crystallographic, spectrometric and spectroscopic analyses, we demonstrate that the anti-cancer drug oxaliplatin efficiently binds angiogenin. Microscopy cellular studies, carried out on the prostate cancer cell (PC-3) line , show that oxaliplatin inhibits the angiogenin prompting effect on cell proliferation and migration, which are typical features of angiogenesis process. Overall, our findings point to angiogenin as a possible target of oxaliplatin, thus suggesting a potential novel mechanism for the antineoplastic activity of this platinum drug and opening the avenue to novel approaches in the combined anti-cancer anti-angiogenic therapy. | ||
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| + | Oxaliplatin inhibits angiogenin proliferative and cell migration effects in prostate cancer cells.,Marzo T, Ferraro G, Cucci LM, Pratesi A, Hansson O, Satriano C, Merlino A, La Mendola D J Inorg Biochem. 2022 Jan;226:111657. doi: 10.1016/j.jinorgbio.2021.111657. Epub , 2021 Nov 9. PMID:34784565<ref>PMID:34784565</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7npm" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ferraro G]] | [[Category: Ferraro G]] | ||
[[Category: Merlino A]] | [[Category: Merlino A]] | ||
Revision as of 20:37, 12 April 2023
X-ray structure of the adduct formed upon reaction of oxaliplatin with human angiogenin
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