6a96

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Current revision (10:09, 15 November 2023) (edit) (undo)
 
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<SX load='6a96' size='340' side='right' viewer='molstar' caption='[[6a96]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
<SX load='6a96' size='340' side='right' viewer='molstar' caption='[[6a96]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6a96]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A96 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6a96]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A96 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABRB3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GABRA5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [https://pdbe.org/6a96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [https://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a96 OCA], [https://pdbe.org/6a96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a96 RCSB], [https://www.ebi.ac.uk/pdbsum/6a96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a96 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [[https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
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[https://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
==See Also==
==See Also==
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Camelus glama]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bi, G Q]]
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[[Category: Bi GQ]]
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[[Category: Cui, Y]]
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[[Category: Cui Y]]
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[[Category: Guan, F]]
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[[Category: Guan F]]
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[[Category: Liu, S]]
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[[Category: Liu S]]
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[[Category: Liu, Y T]]
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[[Category: Liu YT]]
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[[Category: Xu, L]]
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[[Category: Xu L]]
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[[Category: Ye, S]]
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[[Category: Ye S]]
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[[Category: Zhang, Q]]
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[[Category: Zhang Q]]
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[[Category: Zhang, X]]
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[[Category: Zhang X]]
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[[Category: Zhou, Z H]]
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[[Category: Zhou ZH]]
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[[Category: Iron channel]]
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[[Category: Membrane protein]]
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Current revision

Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25

6a96, resolution 3.51Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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