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7p6s

From Proteopedia

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Current revision (07:52, 1 May 2024) (edit) (undo)
 
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<StructureSection load='7p6s' size='340' side='right'caption='[[7p6s]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='7p6s' size='340' side='right'caption='[[7p6s]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7p6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P6S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7p6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P6S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9JE:pentane-1,5-diol'>9JE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7p6r|7p6r]], [[7p6t|7p6t]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9JE:pentane-1,5-diol'>9JE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p6s OCA], [https://pdbe.org/7p6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p6s RCSB], [https://www.ebi.ac.uk/pdbsum/7p6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p6s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p6s OCA], [https://pdbe.org/7p6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p6s RCSB], [https://www.ebi.ac.uk/pdbsum/7p6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p6s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GP2_HUMAN GP2_HUMAN]] Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.<ref>PMID:19907495</ref>
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[https://www.uniprot.org/uniprot/GP2_HUMAN GP2_HUMAN] Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.<ref>PMID:19907495</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy.
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Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.,Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L Nat Struct Mol Biol. 2022 Mar;29(3):190-193. doi: 10.1038/s41594-022-00729-3., Epub 2022 Mar 10. PMID:35273390<ref>PMID:35273390</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7p6s" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Jovine, L]]
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[[Category: Jovine L]]
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[[Category: Jumper, J]]
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[[Category: Jumper J]]
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[[Category: Sanctis, D de]]
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[[Category: Stsiapanava A]]
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[[Category: Stsiapanava, A]]
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[[Category: Tunyasuvunakool K]]
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[[Category: Tunyasuvunakool, K]]
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[[Category: De Sanctis D]]
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[[Category: Alphafold]]
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[[Category: Antimicrobial protein]]
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[[Category: D10c domain]]
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[[Category: D8c sequence]]
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[[Category: Decoy module]]
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[[Category: Extracellular matrix]]
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[[Category: Fimh]]
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[[Category: Glycoprotein]]
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[[Category: Intestine]]
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[[Category: Mucosal immunity]]
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[[Category: N-glycan]]
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[[Category: Pancrea]]
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[[Category: Structural protein]]
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Current revision

Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form II)

PDB ID 7p6s

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